Conjugated isomers of linoleic acid CLA were studied mainly for antineoplastic activity.

Prostaglandins – hormones developing fatty and neoplastic tissues – they are created in an organism from linoleic acid, present in consumable fats. Luckily, the so-called conjugated position isomers are also present in fats in small amounts which, due to a different spatial structure of molecules, inhibits the formation of prostaglandins instead of stimulating it. With significant contribution of CLA in a diet, much fewer prostaglandins are formed and then, fatty cells dependent on them, undergo apoptosis, which considerably facilitates the reduction of fat reserves. Since, extrapolating the effect on cancer cells, also their death can be expected, numerous studies have been performed which aimed at confirming or disavowing the presumptions. And so, e.g. in the studies by professor E.A. Decker, published in Nutrition Reviu, CLA inhibited the development of the carcinomas of the skin, the stomach and the mammary gland.  Since we can read in the conclusion that the expected effective prophylactic dose for people is 1.5 - 3 g daily, it is worth using a CLA supplement as the similar value would be difficult to achieve sticking to the normocaloric diet.